We might be wrestling with the basic dilemmas of the human experience: the inevitability of death; the search for meaning; personal responsibility; a feeling of isolation.
These are all core issues that can come up, and that merit our attention and concern. As Einstein has said, the most important question that a human being needs to address is whether or not the universe is a friendly one.
The way that we decide to structure our worldview has a huge impact on our experience and satisfaction in life. Some people find it helpful to address these issues in psychotherapy.